COLLOIDAL MICROCRYSTALLINE CELLULOSE CO-PROCESSED WITH CMC
 

ALFACEL-P(CC) is the trade name for Sodium CMC blended MCC manufactured by the Company. Microcrystalline Cellulose manufactured by the Company is very good for tableting, however the addition of some quantity of NaCMC to MCC results in its having amazing rheological properties and hence serving a wonderful magical suspending agent for preparation of Colloidal dispersions.

                                        

 

SPECIFICATIONS
     
 

 

The product conforms to the standards of NF, BP

SPECIFICATION OF GRADES OF ALFACEL P(CC)

Alfacel P(CC)
501
Alfacel P(CC)
581
Alfacel P(CC)
59
1
Alfacel P(CC)
611
         
Moisture Content
(when Shipped)
< 6.0%
< 6.0%
< 6.0%
< 6.0%
Heavy Metals
pH (1-2% solid dispersion)
< 10 ppm
6 to 8
< 10 ppm
6 to 8
< 10 ppm
6 to 8
< 10 ppm
6 to 8
Residue on Ignition Percent NaCMC
< 5.0 %
8.5 ±2.1
< 5.0 %
11.0 ± 2.7
< 5.0 %
11.0 ± 2.7
< 5.0 %
11.3 - 18.8
Powder Particle
size
60 mesh< 0.1%
200 mesh<35.0%
60 mesh< 0.1%
200 mesh<35.0%
60 mesh< 0.1%
325 mesh<45.0%
60 mesh< 0.1%
325 mesh<75.0%
Viscosity, cps
2.1% Solution
1.2% Solution
2.6% Solution

120 ± 48
--

--
120 ±48

--
65 ± 26


--
--
50- 151

         
         

 

PRODUCT BENEFITS

A few of these amazing properties are :

  • Diverse Applications
  • High temperature does not change products.
  • Better rheological properties
  • Leaves no resident chalky, drying effect.
  • No phase separation for shelf-life of product.
  • Helps mask unpleasant drug or oily tastes.
  • Thixotropy evident with levels as low as 1%.
  • Temperature changes have little effect or no effect on viscosity.

Alfacel-P(CC)
There are four types of Alfacel-P(CC) as mentioned in the above table. All types are white, odourless and tasteless hygroscopic powders. They are insoluble in organic solvents and dilute acids, & partially soluble in both dilute alkali & water (CMC fraction).

 

APPLICATIONS
The broad scope of applications for Alfacel-P(CC) is demonstrated by the following list.
O/W Emulsifier : pharmaceutical and cosmetic lotions and creams
Emulsion stabilizer : pharmaceutical and cosmetic creams
Foam stabilizer : Aerosol foams
Suspending agent : Pharmaceutical & cosmetic suspensions, reconstitutable pharmaceutical suspensions, such as antibiotics
Body agent Stiffener Opacifier : Pharmaceutical & cosmetic creams, vaginal gels, cosmetic gels
Food & Additives : Cheese

DISPERSION
The colloidal MCC provides a structured dispersion vehicle while the CMC facilitates dispersion and serves as a protective colloid.
When stirred in water Alfacel-P(CC) powder disperses to form either a colloidal sol or white opaque gel, depending upon the Alfacel-P(CC) concentration.


SUMMARIZING THE BENEFITS
Alfacel-P(CC) is a versatile, colloidal dispersion vehicle with broad pharmaceutical applications:

  • Suspending agent
  • Emulsion stabilizer
  • Oil/water emulsifier
  • Modifies viscosity
  • Possesses thixotropic properties
  • Stable under extreme temperatures
  • Stable over wide pH
  • Long shelf-life stability

DISCLAIMER

PATENTS
Reliance Cellulose Products Limited does not warrant against infringement of patents of third party by reason of any uses made of the product in combination with other material or in the operation of any process, and purchasers assume all risks of patent infringement by reason of any such uses, combination, or operation.

WARRANTY
Because of the numerous factors affecting results, Reliance Cellulose Products ingredients are sold on the understanding that purchasers will make their own tests to determine suitability of these products for their particular purpose. The several uses suggested by Reliance Cellulose Products limited are presented only to assist our customers in exploring possible applications. All information and data presented are believed to be accurate and reliable, but are presented without the assumption of any liability by Reliance Cellulose Products Limited. The information contained in this pamphlet is intended to be general in nature.

 

 

 


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