PRODUCT BENEFITS

• Superior tablet disintegrator.
• Effective at low use levels.
• Superior long term dissolution stability.
• Insensitive to tablet hardness.
• Can be used in both Wet granulation & direct compression

Tablet dissolution can be greatly increased by the use of a super disintegrant. These can employ various mechanisms or combinations of mechanisms to cause rapid tablet breakdown. Water wicking (uptake) and disintegrant swelling represent two means commonly used in determining disintegrant performance. The fibrous nature of Carmecel-P(CC) Croscarmellose sodium gives it outstanding water wicking capabilities and its cross-linked chemical structure creates an insoluble hydrophilic, highly absorbent material which results in good swelling properties. This duel functionality translates into superior disintegration characteristics at very low use levels compared to other super desintegrants.

IN DIRECT COMPRESSION

To increase drug dissolution in direct compression formulations, Carmecel-P(CC) should be added to the other formulation components and dry blended to a homogeneous mixture prior to the addition of lubricants. This uniform distribution of Carmecel-P(CC) in the tablet matrix enables it to wick water and swell, thereby breaking the tablet apart and exposing more surface area of the drug to gastric fluids.

IN WET GRANULATION

In most cases, Carmecel-P(CC) should be added during the wet granulation process and to the dry granules prior to compression. This improves drug dissolution by taking full advantage of its wicking and swelling properties.

The addition of Carmecel -P(CC) during the wet mixing phase results in an intimate mixture of Carmecel-P(CC), drug, binder and filler within the granular matrix. This intragranular distribution of Carmecel-P(CC) allows it to break down the granules by swelling and exposes greater surface area of the drug to gastric fluids.

Adding Carmecel-P(CC) during dry blending phase integrates Carmecel-P(CC) into the extragranular structure of the tablet, where its fibrous nature, wicking ability and swelling properties carry fluid throughout the tablet to cause rapid disintegration.

This combined intragranular and extragranular distribution of Carmecel-P(CC) optimizes its functionality.